The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI

被引：28

作者：

Harrington, Karra D. ^{[1
,2
]}

Lim, Yen Ying ^{[1
,3
]}

Ellis, Kathryn A. ^{[1
,3
,4
]}

Copolov, Carly ^{[1
]}

Darby, David ^{[1
]}

Weinborn, Michael ^{[5
]}

Ames, David ^{[4
,6
]}

Martins, Ralph N. ^{[7
]}

Savage, Greg ^{[8
,9
]}

Szoeke, Cassandra ^{[1
,6
]}

Rowe, Christopher ^{[10
,11
,12
]}

Villemagne, Victor L. ^{[1
,10
,11
,12
]}

Masters, Colin L. ^{[1
]}

Maruff, Paul ^{[1
,13
]}

机构：

[1] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[2] RMIT Univ, Sch Psychol, Bundoora, Vic, Australia

[3] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia

[4] Univ Melbourne, St Georges Hosp, Dept Psychiat, Acad Unit Psychiat Old Age, Kew, Vic, Australia

[5] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia

[6] Natl Ageing Res Inst, Parkville, Vic, Australia

[7] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia

[8] Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia

[9] Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW 2109, Australia

[10] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[11] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia

[12] Univ Melbourne, Austin Hlth, Dept Med, Heidelberg, Vic, Australia

[13] CogState Ltd, Melbourne, Vic, Australia

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2013年 / 25卷 / 10期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; mild cognitive impairment; neuroimaging; neuropsychology; NEUROIMAGING INITIATIVE ADNI; ALZHEIMERS-DISEASE; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; IMPAIRMENT; MEMORY; INDIVIDUALS; RECOMMENDATIONS; PERFORMANCE; WORKGROUPS;

D O I：

10.1017/S1041610213001087

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: To date evidence of the relationship between cognition and A beta amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between A beta amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for A beta amyloid. Results: Within the MCI group individuals with high A beta amyloid showed selective impairment for memory compared with those with low A beta amyloid; however, this difference was not evident in the healthy group. Conclusions: The current findings provide further evidence of the relationship between A beta amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.

引用

页码：1667 / 1677

页数：11

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