A capillary electrophoresis chip with hydrodynamic sample injection for measurements from a continuous sample flow

被引：17

作者：

Büttgenbach, S ^{[1
]}

Wilke, R ^{[1
]}

机构：

[1] Tech Univ Braunschweig, Inst Microtechnol, D-38106 Braunschweig, Germany

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2005年 / 383卷 / 05期

关键词：

microchip capillary electrophoresis; on-line monitoring; poly(dimethylsiloxane); hydrodynamic sample injection; ELECTROCHEMICAL DETECTION; MICROCHIP; INTERFACE; SYSTEMS;

D O I：

10.1007/s00216-005-3346-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A microchip-based capillary electrophoresis device supported by a microfluidic network made of poly(dimethylsiloxane), used for measuring target analytes from a continuous sample flow, is presented. The microsystem was fabricated by means of replica molding in combination with standard microfabrication technologies, resulting in microfluidic components and an electrochemical detector. A new hydrodynamic sample injection procedure is introduced, and the maximum number of consecutive measurements that can be made with a poly(dimethylsiloxane) capillary electrophoresis chip with amperometric detection is investigated with respect to reproducibility. The device features a high degree of functional integration, so the benefits associated with miniaturized analysis systems apply to it.

引用

页码：733 / 737

页数：5

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