TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?

被引:122
作者
Zhang, L
Barritt, GJ
机构
[1] Flinders Univ S Australia, Fac Hlth Sci, Sch Med, Dept Med Biochem, Adelaide, SA 5001, Australia
[2] Therapeut Goods Adm, Off Chem Safety, Dept Hlth & Ageing, Woden, ACT 2606, Australia
关键词
D O I
10.1677/erc.1.01093
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
During the past 5 years it has emerged that the transient receptor potential (TRIP) family of Ca2+- and Na+-permeable channels plays a diverse and important role in cell biology and in pathology. One member of this family, TRPM8, is highly expressed in prostate cancer cells but the physiological and pathological functions of TRPM8 in these cells are not known. Here we address these questions, and the issue of whether or not TRPM8 is an effective diagnostic and prognostic marker in prostate cancer. TRPM8 is known to be activated by cool stimuli (17-25 degrees C) and cooling compounds such as menthol. The activation mechanism(s) involves voltage sensing of membrane potential, phosphatidylinositol 4,5-bisphosphate and Ca2+. In addition to prostate cancer cells, TRPM8 is expressed in sensory neurons where it acts as a sensor of cold. In prostate epithelial cells, expression of TRPM8 is regulated by androgen and is elevated in androgen-sensitive cancerous cells compared with normal cells. While there is some evidence that in prostate cancer cells Ca2+ and Na+ inflow through TRPM8 is necessary for survival and function, including secretion at the apical membrane, the function of TRPM8 in these cells is not really known. It may well differ from the role of TRPM8 as a cool sensor in sensory nerve cells. Androgen unresponsive prostate cancer is difficult to treat effectively and there are limited diagnostic and prognostic markers available. TRPM8 is a potential tissue marker in differential diagnosis and a potential prognostic marker for androgen-unresponsive and metastatic prostate cancer. As a consequence of its ability to convey Ca2+ and Na+ and its expression in only a limited number of cell types, TRPM8 is considered to be a promising target for pharmaceutical, immunological and genetic interventions for the treatment of prostate cancer.
引用
收藏
页码:27 / 38
页数:12
相关论文
共 51 条
[1]   TRPM8 protein localization in trigeminal ganglion and taste papillae [J].
Abe, J ;
Hosokawa, H ;
Okazawa, M ;
Kandachi, M ;
Sawada, Y ;
Yamanaka, K ;
Matsumura, K ;
Kobayashi, S .
MOLECULAR BRAIN RESEARCH, 2005, 136 (1-2) :91-98
[2]   TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH [J].
Andersson, DA ;
Chase, HWN ;
Bevan, S .
JOURNAL OF NEUROSCIENCE, 2004, 24 (23) :5364-5369
[3]   Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor [J].
Babes, A ;
Zorzon, D ;
Reid, G .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (09) :2276-2282
[4]   Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay [J].
Behrendt, HJ ;
Germann, T ;
Gillen, C ;
Hatt, H ;
Jostock, R .
BRITISH JOURNAL OF PHARMACOLOGY, 2004, 141 (04) :737-745
[5]   Evidence for specific TRPM8 expression in human prostate secretory epithelial cells:: functional androgen receptor requirement [J].
Bidaux, G ;
Roudbaraki, M ;
Merle, C ;
Crépin, A ;
Delcourt, P ;
Slomianny, C ;
Thebault, S ;
Bonnal, JL ;
Benahmed, M ;
Cabon, F ;
Mauroy, B ;
Prevarskaya, N .
ENDOCRINE-RELATED CANCER, 2005, 12 (02) :367-382
[6]   2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release [J].
Bootman, MD ;
Collins, TJ ;
Mackenzie, L ;
Roderick, HL ;
Berridge, MJ ;
Peppiatt, CM .
FASEB JOURNAL, 2002, 16 (10) :1145-1150
[7]   Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8 [J].
Brauchi, S ;
Orio, P ;
Latorre, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (43) :15494-15499
[8]   ALLELIC LOSS OF CHROMOSOME-16Q AND CHROMOSOME-10Q IN HUMAN PROSTATE-CANCER [J].
CARTER, BS ;
EWING, CM ;
WARD, WS ;
TREIGER, BF ;
AALDERS, TW ;
SCHALKEN, JA ;
EPSTEIN, JI ;
ISAACS, WB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8751-8755
[9]   The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel [J].
Chuang, HH ;
Neuhausser, WM ;
Julius, D .
NEURON, 2004, 43 (06) :859-869
[10]   TRP channels as cellular sensors [J].
Clapham, DE .
NATURE, 2003, 426 (6966) :517-524