Altering protein turnover in tumor cells: New opportunities for anti-cancer therapies

被引：38

作者：

Demarchi, F

Brancolini, C

机构：

[1] Univ Udine, Dipartimento Sci & Tecnol Biomed, Sez Biol, I-33100 Udine, Italy

[2] Lab Nazl Consorzio Interuniv Biotecnol, I-34100 Trieste, Italy

来源：

DRUG RESISTANCE UPDATES | 2005年 / 8卷 / 06期

关键词：

apoptosis; caspases; IAP; IBM; bortezomib; bcl-2; mitochondria; death receptors; apoptosome; hsp; p53; NF-kappa B; noxa; Mcl-1; ubiquitin; proteasome;

D O I：

10.1016/j.drup.2005.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The promising effects of the proteasome inhibitor bortezomib (Veleade, PS-341) in the treatment of certain types of cancer have fired up the interest on this multicatalytic proteolytic machinery. A number of recent reviews thoroughly describe various aspects of the ubiquitin-proteasome system and its importance in the control of cell growth and tumorigenesis. Here, we will focus on recent data unveiling a link between the proteasome and some elements of the apoptotic machinery including Bcl-2 members, caspases, IAPs and IAP antagonists. Perturbing their turnover significantly contributes to the apoptotic response and the anti-neoplastic activity of proteasome inhibitors. (C) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：359 / 368

页数：10

相关论文

共 102 条

[71] The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development [J].

Ren, JY ;

Shi, MG ;

Liu, RS ;

Yang, QH ;

Johnson, T ;

Skarnes, WC ;

Du, CY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) :565-570

[72]

Richardson PG, 2005, CELL CYCLE, V4, P290

[73] INHIBITORS OF THE PROTEASOME BLOCK THE DEGRADATION OF MOST CELL-PROTEINS AND THE GENERATION OF PEPTIDES PRESENTED ON MHC CLASS-I MOLECULES [J].

ROCK, KL ;

GRAMM, C ;

ROTHSTEIN, L ;

CLARK, K ;

STEIN, R ;

DICK, L ;

HWANG, D ;

GOLDBERG, AL .

CELL, 1994, 78 (05) :761-771

[74] IAP proteins: Blocking the road to death's door [J].

Salvesen, GS ;

Duckett, CS .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (06) :401-410

[75] The proteasorne inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP [J].

Sayers, TJ ;

Brooks, AD ;

Koh, CY ;

Ma, WH ;

Seki, N ;

Raziuddin, A ;

Blazar, BR ;

Zhang, X ;

Elliott, PJ ;

Murphy, WJ .

BLOOD, 2003, 102 (01) :303-310

[76] Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice [J].

Schimmer, AD .

CANCER RESEARCH, 2004, 64 (20) :7183-7190

[77] Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity [J].

Schimmer, AD ;

Welsh, K ;

Pinilla, C ;

Wang, ZL ;

Krajewska, M ;

Bonneau, MJ ;

Pedersen, IM ;

Kitada, S ;

Scott, FL ;

Bailly-Maitre, B ;

Glinsky, G ;

Scudiero, D ;

Sausville, E ;

Salvesen, G ;

Nefzi, A ;

Ostresh, JM ;

Houghten, RA ;

Reed, JC .

CANCER CELL, 2004, 5 (01) :25-35

[78] Mechanisms of cytochrome c release by proapoptotic BCL-2 family members [J].

Scorrano, L ;

Korsmeyer, SJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (03) :437-444

[79] XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs [J].

Scott, FL ;

Denault, JB ;

Riedl, SJ ;

Shin, H ;

Renatus, M ;

Salvesen, GS .

EMBO JOURNAL, 2005, 24 (03) :645-655

[80] Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology [J].

Shiozaki, EN ;

Shi, YG .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (09) :486-494

← 2 3 4 5 6 7 8 9 10 11 →