The exon sequence TAGG can inhibit splicing

被引:58
作者
DelGatto, F [1 ]
Gesnel, MC [1 ]
Breathnach, R [1 ]
机构
[1] INST BIOL,INSERM U211,F-44035 NANTES 01,FRANCE
关键词
D O I
10.1093/nar/24.11.2017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The fibroblast growth factor receptor-2 gene contains a pair of alternative exons, K-SAM and BEK, which are spliced in a cell type specific manner, We have shown previously that a 10 nucleotide sequence within the K-SAM exon exerts a negative effect on K-SAM exon splicing independent of cell type, We demonstrate here that this sequence works autonomously, as it can repress splicing of a heterologous exon, the EIIIb alternative exon of the rat fibronectin gene, By introducing point mutations into the 10 nucleotide sequence, we have shown that the functional portion is limited to 4 nucleotides, TACO, the dinucleotide AG of which is particularly important. This short sequence may participate in the control of splicing of exons carrying it, provided that they carry weak splice sites.
引用
收藏
页码:2017 / 2021
页数:5
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