Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders

被引：42

作者：

Gunning, Patrick T. ^{[2
]}

Glenn, Matthew P. ^{[2
]}

Siddiquee, Khandaker A. Z. ^{[1
]}

Katt, William P. ^{[2
]}

Masson, Eric ^{[2
]}

Sebti, Said M. ^{[3
,4
]}

Turkson, James ^{[1
]}

Hamilton, Andrew D. ^{[2
]}

机构：

[1] Univ Cent Florida, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[3] Univ S Florida, Drug Discovery Program, H Lee Moffitt Canc Ctr & Res Inst, Dept Oncol, Tampa, FL 33612 USA

[4] Univ S Florida, Dept Biochem & Mol Biol, Tampa, FL 33612 USA

来源：

CHEMBIOCHEM | 2008年 / 9卷 / 17期

关键词：

antitumor agents; molecular recognition; protein-protein interactions; small molecules; Stat3;

D O I：

10.1002/cbic.200800291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

[No abstract available]

引用

页码：2800 / 2803

页数：4

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