DDQ/TBHP-Induced Oxidative Cyclization Process: A Metal-Free Approach for the Synthesis of 2-Phenylquinazolines

被引：17

作者：

Rachakonda, Sridhar ^{[2
]}

Pratap, P. Surya ^{[1
]}

Rao, Mandava V. Basaveswara ^{[1
]}

机构：

[1] Krishna Univ, Dept Chem, Machilipatnam 521001, AP, India

[2] KL Univ, Dept Chem, Guntur 522502, AP, India

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 13期

关键词：

2-aminobenzophenones; 2-aminoacetophenones; benzylamines; 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; 2-phenylquinazolines; oxidative cyclization; SP(3) C-H; QUINAZOLINE; INHIBITORS; ACID; 2,3-DICHLORO-5,6-DICYANOBENZOQUINONE; DIMERIZATION; DERIVATIVES; REPLACEMENT; QUINOLINE; RECEPTOR;

D O I：

10.1055/s-0031-1289768

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various 2-phenylquinazoline derivatives were synthesized under metal-free conditions from readily available 2-aminophenyl ketones and benzylamines via condensation and oxidative cyclization using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as a versatile reagent. The reaction gave the corresponding 2-phenylquinazoline derivatives in good to excellent yields (up to 92%).

引用

页码：2065 / 2069

页数：5

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