Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

被引：32

作者：

Aoyagi, Y

Hitotsuyanagi, Y

Hasuda, T

Fukaya, H

Takeya, K

Aiyama, R

Matsuzaki, T

Hashimoto, S

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Yakult Cent Inst Microbiol Res, Kunitachi, Tokyo 1868650, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 07期

关键词：

triptolide analogues; semisynthesis; antitumor; structure-activity relationships; C-ring;

D O I：

10.1016/j.bmcl.2005.12.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1947 / 1949

页数：3

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