Immunosuppressive terpenoids from extracts of Tripterygium wilfordii

被引：71

作者：

Duan, HQ

Takaishi, Y

Momota, H

Ohmoto, Y

Taki, T

Tori, M

Takaoka, S

Jia, YF

Li, D

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Tokushima 7710192, Japan

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

[4] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON | 2001年 / 57卷 / 40期

关键词：

Tripterygium wilfordii; Celastraceae; triterpenes; diterpenes; immunosuppressive activity; triptolide;

D O I：

10.1016/S0040-4020(01)00724-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The clinically used extract (T-Pi) of Tripterygium wilfordii Hook f. give 19 new compounds, including five kaurane diterpenes (1-5), one manoyl oxide diterpene (6), and one abietane diterpene, (7), three ursene triterpenes (8, 9 and 15), six oleanane triterpenes (10-13, 16 and 19), and three friedelane triterpenes (14, 17 and 18), as well as 15 known compounds (20-34). Their structures were elucidated by spectroscopy and X-ray analysis. Based on the screening of isolated compounds and other compounds reported in previous papers [J. Nat. Prod. 62 (1999) 1522; J. Nat. Prod. (2001) in press; Phytochemistry 53 (2000) 805], we identified the main components that are responsible for the therapeutic effect of T-Pi. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8413 / 8424

页数：12

共 33 条

[1]

[Anonymous], [No title captured], Patent No. [WO 9420488, 9420488]

[2] LABDANE DITERPENES FROM CISTUS SYMPHYTIFOLIUS [J].

CALABUIG, MT ;

CORTES, M ;

FRANCISCO, CG ;

HERNANDEZ, R ;

SUAREZ, E .

PHYTOCHEMISTRY, 1981, 20 (09) :2255-2258

[3] ANTI-AIDS AGENTS .19. NEOTRIPTERIFORDIN, A NOVEL ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII - ISOLATION AND STRUCTURAL ELUCIDATION [J].

CHEN, K ;

SHI, QA ;

FUJIOKA, T ;

NAKANO, T ;

HU, CQ ;

JIN, JQ ;

KILKUSKIE, RE ;

LEE, KH .

BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (10) :1345-1348

[4] Di- and triterpenoids from Tripterygium hypoglaucum [J].

Duan, HG ;

Kawazoe, K ;

Bando, M ;

Kido, M ;

Takaishi, Y .

PHYTOCHEMISTRY, 1997, 46 (03) :535-543

[5] Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii [J].

Duan, HQ ;

Takaishi, Y ;

Momota, H ;

Ohmoto, Y ;

Taki, T ;

Jia, YF ;

Li, D .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :582-587

[6] Sesquiterpene polyol esters from Tripterygium wilfordii [J].

Duan, HQ ;

Takaishi, Y ;

Jia, YF ;

Li, D .

PHYTOCHEMISTRY, 2001, 56 (04) :341-346

[7] Immunosuppressive diterpenoids from Tripterygium wilfordii [J].

Duan, HQ ;

Takaishi, Y ;

Momota, H ;

Ohmoto, Y ;

Taki, T ;

Jia, YF ;

Li, D .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (11) :1522-1525

[8] Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii:: A new class of potent anti-HIV agents [J].

Duan, HQ ;

Takaishi, Y ;

Imakura, Y ;

Jia, YF ;

Li, D ;

Cosentino, LM ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (03) :357-361

[9] Triterpenoids from Tripterygium wilfordii [J].

Duan, HQ ;

Takaishi, Y ;

Momota, H ;

Ohmoto, Y ;

Taki, T ;

Jia, YF ;

Li, D .

PHYTOCHEMISTRY, 2000, 53 (07) :805-810

[10]

Duan HQ, 1999, CHEM PHARM BULL, V47, P1664

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