Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii

被引：80

作者：

Duan, HQ

Takaishi, Y

Momota, H

Ohmoto, Y

Taki, T

Jia, YF

Li, D

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Tokushima 7710192, Japan

[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 05期

关键词：

D O I：

10.1021/np000504a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T-II) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

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页码：582 / 587

页数：6

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