Immunosuppressive diterpenoids from Tripterygium wilfordii

被引：71

作者：

Duan, HQ

Takaishi, Y

Momota, H

Ohmoto, Y

Taki, T

Jia, YF

Li, D

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan

[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 11期

关键词：

D O I：

10.1021/np9902183

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A clinically us ed extract of Tripterygium wilfordii afforded three new diterpenoids-3 beta,19-dihydroxyabieta-8,11,13-triene (triptobenzene L) (1); 12,19-dihydroxy-3-oxoabieta-8,11,13-triene (triptobenzene M) (2); and 19-hydroxy-3,7-dioxo-abieta-8,11,13-triene (triptobenzene N) (3)-along with 14 known diterpenoids. The structures of 1-3 were established on the basis of spectroscopic studies. Of the known compounds, the stereochemistry at C-4 of triptonediol (4) was reassigned. Tripterifordin (8) and 13-epi-manoyl oxide-18-oic acid (9) showed significant inhibitory effects on cytokine production.

引用

页码：1522 / 1525

页数：4

共 18 条

[1] ANTI-AIDS AGENTS .19. NEOTRIPTERIFORDIN, A NOVEL ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII - ISOLATION AND STRUCTURAL ELUCIDATION [J].