Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii:: A new class of potent anti-HIV agents

被引：103

作者：

Duan, HQ

Takaishi, Y

Imakura, Y

Jia, YF

Li, D

Cosentino, LM

Lee, KH

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Naruto Univ Educ, Fac Sci, Tokushima 7728502, Japan

[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

[4] BBI Biotech Res Labs, Gaithersburg, MD 20877 USA

[5] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 03期

关键词：

D O I：

10.1021/np990281s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wildfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC50 value of <0.10 mu g/mL and an in vitro therapeutic index value of > 1000.

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页码：357 / 361

页数：5

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