The tiger genome and comparative analysis with lion and snow leopard genomes

被引：217

作者：

Cho, Yun Sung ^{[1
]}

Hu, Li ^{[2
]}

Hou, Haolong ^{[2
]}

Lee, Hang ^{[3
,4
]}

Xu, Jiaohui ^{[2
]}

Kwon, Soowhan ^{[5
]}

Oh, Sukhun ^{[5
]}

Kim, Hak-Min ^{[1
]}

Jho, Sungwoong ^{[1
]}

Kim, Sangsoo ^{[6
]}

Shin, Young-Ah ^{[1
]}

Kim, Byung Chul ^{[1
,7
]}

Kim, Hyunmin ^{[7
]}

Kim, Chang-uk ^{[1
]}

Luo, Shu-Jin ^{[8
]}

Johnson, Warren E. ^{[9
]}

Koepfli, Klaus-Peter ^{[10
]}

Schmidt-Kuentzel, Anne ^{[11
]}

Turner, Jason A. ^{[12
]}

Marker, Laurie ^{[13
]}

Harper, Cindy ^{[14
]}

Miller, Susan M. ^{[14
,15
]}

Jacobs, Wilhelm ^{[16
]}

Bertola, Laura D. ^{[17
]}

Kim, Tae Hyung ^{[7
]}

Lee, Sunghoon ^{[1
,7
]}

Zhou, Qian ^{[2
]}

Jung, Hyun-Ju ^{[7
]}

Xu, Xiao ^{[8
]}

Gadhvi, Priyvrat ^{[1
]}

Xu, Pengwei ^{[2
]}

Xiong, Yingqi ^{[2
]}

Luo, Yadan ^{[2
]}

Pan, Shengkai ^{[2
]}

Gou, Caiyun ^{[2
]}

Chu, Xiuhui ^{[2
]}

Zhang, Jilin ^{[2
]}

Liu, Sanyang ^{[2
]}

He, Jing ^{[2
]}

Chen, Ying ^{[2
]}

Yang, Linfeng ^{[2
]}

Yang, Yulan ^{[2
]}

He, Jiaju ^{[2
]}

Liu, Sha ^{[2
]}

Wang, Junyi ^{[2
]}

Kim, Chul Hong ^{[7
]}

Kwak, Hwanjong ^{[7
]}

Kim, Jong-Soo ^{[1
]}

Hwang, Seungwoo ^{[18
]}

Ko, Junsu ^{[7
]}

机构：

[1] Genome Res Fdn, Personal Genom Inst, Suwon 443270, South Korea

[2] BGI Shenzhen, Shenzhen 518083, Peoples R China

[3] Seoul Natl Univ, Tiger & Leopard Conservat Fund Korea, Seoul 151742, South Korea

[4] Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea

[5] Samsung Everland Zoo, Yongin 449715, South Korea

[6] Soongsil Univ, Sch Syst Biomed Sci, Seoul 156743, South Korea

[7] TheragenEtex, Theragen BiO Inst, Suwon 443270, South Korea

[8] Peking Univ, Sch Life Sci, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

[9] Smithsonian Conservat Biol Inst, Front Royal, VA 22630 USA

[10] St Petersburg State Univ, Theodosius Dobzhansky Ctr Genome Bioinformat, St Petersburg 199034, Russia

[11] Cheetah Conservat Fund, Life Technol Conservat Genet Lab, Otjiwarongo 9000, Namibia

[12] Tsau Conservancy, Global White Lion Protect Trust, ZA-1380 Limpopo, South Africa

[13] Cheetah Conservat Fund, Otjiwarongo 9000, Namibia

[14] Univ Pretoria, Fac Vet Sci, Vet Genet Lab, ZA-0110 Onderstepoort, South Africa

[15] Tshwane Univ Technol, Nat Conservat Dept, ZA-0001 Pretoria, South Africa

[16] Ukutula Lodge & Lion Ctr, ZA-0250 Brits, Northwest Provi, South Africa

[17] Leiden Univ, Inst Environm Sci CML, NL-2300 RA Leiden, Netherlands

[18] Korea Res Inst Biosci & Biotechnol, Korean Bioinformat Ctr, Taejon 305806, South Korea

[19] Sangmyung Univ, Dept Life Sci, Seoul 110743, South Korea

[20] Sungshin Womens Univ, Dept Biol, Seoul 142732, South Korea

[21] Natl Univ Mongolia, Sch Biol & Biotechnol, Dept Mol Biol & Genet, Ulaanbaatar 210646A, Mongolia

[22] Natl Sci Museum, Taejon 305705, South Korea

[23] CHA Univ, CHA Canc Inst, Seoul 135081, South Korea

[24] Nova SE Univ, Oceanog Ctr, Ft Lauderdale, FL 33004 USA

[25] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[26] King Abdulaziz Univ, Jeddah 21589, Saudi Arabia

[27] Adv Inst Convergence Technol Nano Sci & Technol, Suwon 443270, South Korea

[28] Seoul Natl Univ, Dept Transdisciplinary Studies, Program Nano Sci & Technol, Suwon 443270, South Korea

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

基金：

新加坡国家研究基金会;

关键词：

ALIGNMENT; SEQUENCE; ADAPTATION; PREDICTION; TYROSINASE; INSIGHTS; DATABASE; HISTORY; SEARCH;

D O I：

10.1038/ncomms3433

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39 > Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G > A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.

引用

页数：7

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