Late-Stage Fluorination: From Fundamentals to Application

被引：163

作者：

Campbell, Michael G. ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2014年 / 18卷 / 04期

基金：

美国国家科学基金会;

关键词：

COPPER-MEDIATED FLUORINATION; BETA-FLUORIDE ELIMINATION; BOND FORMATION; TRIFLUOROMETHYL TRIFLATE; REDUCTIVE ELIMINATION; ARYL STANNANES; F BOND; PALLADIUM; CHEMISTRY; MECHANISM;

D O I：

10.1021/op400349g

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this brief account, we review work from our lab with a focus on late-stage introduction of fluorine and fluorinated functional groups into small molecules. We attempt to highlight practical developments, which we believe may have potential for industrial applications, and critically reflect on developments that may not yet meet the bar for practical use.

引用

页码：474 / 480

页数：7

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