Evaluation of the residual solvent content of counterfeit tablets and capsules

被引：22

作者：

Deconinck, E. ^{[1
]}

Canfyn, M. ^{[1
]}

Sacre, P. -Y. ^{[1
,2
]}

Courselle, P. ^{[1
]}

De Beer, J. O. ^{[1
]}

机构：

[1] Sci Inst Publ Hlth WIV ISP, Div Food Med & Consumer Safety, Sect Med Prod, B-1050 Brussels, Belgium

[2] Univ Liege, CIRM, Analyt Chem Lab, B-4000 Liege, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2013年 / 81-82卷

关键词：

Counterfeit medicines; Gas chromatography; Residual solvents; Mass spectrometry; Secondary components; CHROMATOGRAPHY-MASS SPECTROMETRY; STRUCTURE ELUCIDATION; STRUCTURAL ELUCIDATION; SILDENAFIL CITRATE; VARDENAFIL; ANALOG; ADULTERANT; VIAGRA(R); IDENTIFICATION; FORMULATIONS;

D O I：

10.1016/j.jpba.2013.03.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

A group of counterfeit samples of Viagra (R) and Cialis (R) were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：80 / 88

页数：9

共 36 条

[1]

Amin AS, 2009, J AOAC INT, V92, P125

[2]

[Anonymous], 2005, European patent, Patent No. [EP 1633364 A2, 1633364]

[3]

[Anonymous], 2010, European patent, Patent No. [EP2181997 A1, 2181997]

[4]

[Anonymous], 1997, INT C HARM ICH TECHN

[5]

[Anonymous], 2010, EUR PHARM 7 0

[6]

[Anonymous], 2011, JAP PHARM

[7]

Structure elucidation of sildenafil analogues in herbal products [J].

Blok-Tip, L ;

Zomer, B ;

Bakker, F ;

Hartog, KD ;

Hamzink, M ;

ten Hove, J ;

Vredenbregt, M ;

de Kaste, D .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2004, 21 (08) :737-748

[8]

Croux C., 1996, COMPSTAT P COMP STAT

[9]

Detection of counterfeit Viagra® with Raman spectroscopy [J].

de Veij, Marleen ;

Deneckere, Annelien ;

Vandenabeele, Peter ;

de Kaste, Dries ;

Moens, Luc .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 46 (02) :303-309

[10]

A validated GC-MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules [J].

Deconinck, E. ;

Canfyn, M. ;

Sacre, P. -Y. ;

Baudewyns, S. ;

Courselle, P. ;

De Beer, J. O. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 70 :64-70

← 1 2 3 4 →