Protein microarrays for diagnostic assays

被引:122
作者
Hartmann, Michael [1 ,2 ]
Roeraade, Johan [2 ]
Stoll, Dieter [1 ]
Templin, Markus F. [1 ]
Joos, Thomas O. [1 ]
机构
[1] Univ Tubingen, NMI Nat & Med Sci Inst, D-72770 Reutlingen, Germany
[2] Royal Inst Technol, Sch Chem Sci & Engn, Dept Analyt Chem, S-10044 Stockholm, Sweden
关键词
Protein microarrays; Multiplexed diagnostics; In-vitro diagnostics; Focused protein-profiling; Analytical microarrays; ROLLING-CIRCLE AMPLIFICATION; ANTIBODY MICROARRAYS; TECHNOLOGY; IMMUNOASSAY; SYSTEM; PROTEOMICS; SPECIMENS; DISEASES; ANTIGENS; SERUM;
D O I
10.1007/s00216-008-2379-z
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Protein microarray technology has enormous potential for in vitro diagnostics (IVD). Miniaturized parallelized immunoassays are perfectly suited to generating a maximum of diagnostically relevant information from minute amounts of sample whilst only requiring small amounts of reagent. Protein microarrays have become well-established research tools in basic and applied research and the first products are already on the market. This article reviews the current state of protein microarrays and discusses developments and future demands relating to protein arrays in their role as multiplexed immunoassays in the field of diagnostics.
引用
收藏
页码:1407 / 1416
页数:10
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