Bio-microarray fabrication techniques - A review

被引:274
作者
Barbulovic-Nad, Irena
Lucente, Michael
Sun, Yu
Zhang, Mingjun
Wheeler, Aaron R.
Bussmann, Markus
机构
[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G9, Canada
[3] Agilent Technol, Palo Alto, CA USA
[4] Univ Toronto, Dept Chem, Toronto, ON M5S 3G9, Canada
[5] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3G9, Canada
关键词
DNA microarray; contact pins; contact printing; inkjet; microstamps; non-contact printing; photolithography; protein microarray;
D O I
10.1080/07388550600978358
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Microarrays with biomolecules (e.g., DNA and proteins), cells, and tissues immobilized on solid substrates are important tools for biological research, including genomics, proteomics, and cell analysis. In this paper, the current state of microarray fabrication is reviewed. According to spot formation techniques, methods are categorized as "contact printing" and "non-contact printing". Contact printing is a widely used technology, comprising methods such as contact pin printing and microstamping. These methods have many advantages, including reproducibility of printed spots and facile maintenance, as well as drawbacks, including low-throughput fabrication of arrays. Non-contact printing techniques are newer and more varied, comprising photochemistry-based methods, laser writing, electrospray deposition, and inkjet technologies. These technologies emerged from other applications and have the potential to increase microarray fabrication throughput; however, there are several challenges in applying them to microarray fabrication, including interference from satellite drops and biomolecule denaturization.
引用
收藏
页码:237 / 259
页数:23
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