Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency

被引：24

作者：

Donehower, Lawrence A. ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

来源：

AGING-US | 2012年 / 4卷 / 10期

关键词：

LIFE-SPAN;

D O I：

10.18632/aging.100494

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：660 / 661

页数：2

共 7 条

[1] Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice [J].

Anisimov, Vladimir N. ;

Zabezhinski, Mark A. ;

Popovich, Irina G. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Antoch, Marina P. ;

Blagosklonny, Mikhail V. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) :2092-2097

[2]

[Anonymous], 2011, GENES CANC

[3]

Comas M, 2012, AGING, P4

[4] 20 years studying p53 functions in genetically engineered mice [J].

Donehower, Lawrence A. ;

Lozano, Guillermina .

NATURE REVIEWS CANCER, 2009, 9 (11) :830-840

[5] Rapamycin fed late in life extends lifespan in genetically heterogeneous mice [J].

Harrison, David E. ;

Strong, Randy ;

Sharp, Zelton Dave ;

Nelson, James F. ;

Astle, Clinton M. ;

Flurkey, Kevin ;

Nadon, Nancy L. ;

Wilkinson, J. Erby ;

Frenkel, Krystyna ;

Carter, Christy S. ;

Pahor, Marco ;

Javors, Martin A. ;

Fernandez, Elizabeth ;

Miller, Richard A. .

NATURE, 2009, 460 (7253) :392-U108

[6] Rapamycin slows aging in mice [J].

Wilkinson, John E. ;

Burmeister, Lisa ;

Brooks, Susan V. ;

Chan, Chi-Chao ;

Friedline, Sabrina ;

Harrison, David E. ;

Hejtmancik, James F. ;

Nadon, Nancy ;

Strong, Randy ;

Wood, Lauren K. ;

Woodward, Maria A. ;

Miller, Richard A. .

AGING CELL, 2012, 11 (04) :675-682

[7] mTOR: from growth signal integration to cancer, diabetes and ageing [J].

Zoncu, Roberto ;

Efeyan, Alejo ;

Sabatini, David M. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (01) :21-35

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