The pH-dependence of preferential solvation as studied by intermolecular homo- and heteronuclear NOE measurements of adenosine in water-trifluoroethanol mixtures

被引：14

作者：

Angulo, M ^{[1
]}

Berger, S ^{[1
]}

机构：

[1] Univ Leipzig, Inst Analyt Chem, D-04103 Leipzig, Germany

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2004年 / 378卷 / 06期

关键词：

NMR; intermolecular NOE; preferential solvation; pH dependence; trifluoroethanol; adenosine;

D O I：

10.1007/s00216-003-2308-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A study of the state of solvation of the adenine ring in adenosine and adenosine 5'-monophosphate disodium salt in water and in a (7.5:2.5) water-TFE mixture has been carried out by measurement of homo- and heteronuclear intermolecular NOE enhancements between water or TFE and the aromatic protons of these compounds. The results give evidence of site specificity in solute-solvent interaction for both solvent systems and preferential solvation of the solute by TFE in the water-TFE mixture. Significant pH dependence of these interactions has been discovered.

引用

页码：1555 / 1560

页数：6

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