Micro- and nanotechnology for viral detection

被引:61
作者
Cheng, Xuanhong [2 ]
Chen, Grace [3 ]
Rodriguez, William R. [1 ]
机构
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA
[2] Lehigh Univ, Whitaker Lab, Bethlehem, PA 18015 USA
[3] Massachusetts Gen Hosp, Harvard MIT Hlth Sci & Technol, Charlestown, MA 02119 USA
关键词
Viral diagnosis; Bio-MEMS; Nanotechnology; IMMUNODEFICIENCY-VIRUS TYPE-1; REAL-TIME PCR; MICROFLUIDIC BIOSENSOR; ELECTRICAL DETECTION; SENSITIVE DETECTION; LIGHT-SCATTERING; RAPID DETECTION; DNA DETECTION; WHOLE-BLOOD; CELL-LYSIS;
D O I
10.1007/s00216-008-2514-x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Since the identification of viruses at the start of the 20th century, detecting their presence has presented great challenges. In the past two decades, there has been significant progress in viral detection methods for clinical diagnosis and environmental monitoring. The earliest advances were in molecular biology and imaging techniques. Advances in microfabrication and nanotechnology have now begun to play an important role in viral detection, and improving the detection limit, operational simplicity, and cost-effectiveness of viral diagnostics. Here we provide an overview of recent advances, focusing especially on advances in simple, device-based approaches for viral detection.
引用
收藏
页码:487 / 501
页数:15
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