siRNA Conjugate Delivery Systems

被引：282

作者：

Jeong, Ji Hoon ^{[2
]}

Mok, Hyejung ^{[1
]}

Oh, Yu-Kyoung ^{[3
]}

Park, Tae Gwan ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[2] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

[3] Korea Univ, Sch Life Sci & Biotechnol, Seoul, South Korea

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 01期

关键词：

POLYELECTROLYTE COMPLEX MICELLES; CELL-PENETRATING PEPTIDES; SMALL INTERFERING RNA; POLY(ETHYLENE GLYCOL)-SIRNA CONJUGATE; TAT-DEPENDENT TRANSACTIVATION; CATIONIC FUSOGENIC PEPTIDE; CULTURED-MAMMALIAN-CELLS; INNATE IMMUNE-RESPONSE; TARGETING IN-VIVO; INTRACELLULAR DELIVERY;

D O I：

10.1021/bc800278e

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.

引用

收藏

页码：5 / 14

页数：10

相关论文

共 81 条

[1]

Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[2]

Tolerance for mutations and chemical modifications in a siRNA [J].

Amarzguioui, M ;

Holen, T ;

Babaie, E ;

Prydz, H .

NUCLEIC ACIDS RESEARCH, 2003, 31 (02) :589-595

[3]

Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: Effects on cellular uptake, binding to target sequences, and biologic actions [J].

Astriab-Fisher, A ;

Sergueev, D ;

Fisher, M ;

Shaw, BR ;

Juliano, RL .

PHARMACEUTICAL RESEARCH, 2002, 19 (06) :744-754

[4]

Fully 2′-Deoxy-2′-Fluoro substituted nucleic acids induce RNA interference in mammalian cell culture [J].

Blidner, Richard A. ;

Hammer, Robert P. ;

Lopez, Mandi J. ;

Robinson, Sandra O. ;

Monroe, W. Todd .

CHEMICAL BIOLOGY & DRUG DESIGN, 2007, 70 (02) :113-122

[5]

RNA interference in mammalian cells by chemically-modified RNA [J].

Braasch, DA ;

Jensen, S ;

Liu, YH ;

Kaur, K ;

Arar, K ;

White, MA ;

Corey, DR .

BIOCHEMISTRY, 2003, 42 (26) :7967-7975

[6]

Biodistribution of phosphodiester and phosphorothioate siRNA [J].

Braasch, DA ;

Paroo, Z ;

Constantinescu, A ;

Ren, G ;

Öz, OK ;

Mason, RP ;

Corey, DR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (05) :1139-1143

[7]

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems [J].

Caplen, NJ ;

Parrish, S ;

Imani, F ;

Fire, A ;

Morgan, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9742-9747

[8]

Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-Peptide analogue of insulin-like growth factor 1 [J].

Cesarone, Gregory ;

Edupuganti, Om Prakash ;

Chen, Chang-Po ;

Wickstrom, Eric .

BIOCONJUGATE CHEMISTRY, 2007, 18 (06) :1831-1840

[9]

Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity [J].

Chen, Po Yu ;

Weinmann, Lasse ;

Gaidatzis, Dimos ;

Pei, Yi ;

Zavolan, Mihaela ;

Tuschl, Thomas ;

Meister, Gunter .

RNA, 2008, 14 (02) :263-274

[10]

Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells [J].

Chiu, YL ;

Ali, A ;

Chu, CY ;

Cao, H ;

Rana, TM .

CHEMISTRY & BIOLOGY, 2004, 11 (08) :1165-1175

← 1 2 3 4 5 6 7 8 9 →