MOLECULAR ORIGINS OF CANCER Gene-Expression Signatures in Breast Cancer

被引：1056

作者：

Sotiriou, Christos ^{[1
]}

Pusztai, Lajos ^{[2
]}

机构：

[1] Univ Libre Bruxelles, Dept Med Oncol, Translat Res Unit, Inst Jules Bordet, B-1000 Brussels, Belgium

[2] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 08期

关键词：

PROGNOSTIC SIGNATURE; HISTOLOGIC GRADE; PREDICT SURVIVAL; CLINICAL UTILITY; MICROARRAY DATA; PROFILES; RECEPTOR; SUBTYPES; RECURRENCE; CARCINOMAS;

D O I：

10.1056/NEJMra0801289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review discusses the results of DNA microarray signatures in breast cancer. These signatures have been useful in the classification of breast cancers, and they have an association with clinical outcomes. Surprisingly, there is little overlap in the types of genes among several useful microarray signatures. The true value of these signatures will become apparent only hen prospective trials, now in progress, have been completed. See P. 790 Copyright © 2009 Massachusetts Medical Society.

引用

页码：790 / 800

页数：11

共 93 条

[41] Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas [J].

Kreike, Bas ;

van Kouwenhove, Marieke ;

Horlings, Hugo ;

Weigelt, Britta ;

Peterse, Hans ;

Bartelink, Harry ;

van de Vijver, Marc J. .

BREAST CANCER RESEARCH, 2007, 9 (05)

[42] A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery [J].

Lee, Jae K. ;

Havaleshko, Dmytro M. ;

Cho, HyungJun ;

Weinstein, John N. ;

Kaldjian, Eric P. ;

Karpovich, John ;

Grimshaw, Andrew ;

Theodorescu, Dan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (32) :13086-13091

[43]

Liang H, 2007, BREAST CANCER RES TR, V106, pS105

[44] Are gene signatures better than traditional clinical factors? Authors' reply [J].

Linn, Sabine C. ;

Bueno-de-Mesquita, Jolien M. ;

van de Vijver, Marc J. .

LANCET ONCOLOGY, 2008, 9 (03) :198-199

[45] The prognostic role of a gene signature from tumorigenic breast-cancer cells. [J].

Liu, Rui ;

Wang, Xinhao ;

Chen, Grace Y. ;

Dalerba, Piero ;

Gurney, Austin ;

Hoey, Timothy ;

Sherlock, Gavin ;

Lewicki, John ;

Shedden, Kerby ;

Clarke, Michael F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (03) :217-226

[46] BRCA1 regulates human mammary stem/progenitor cell fate [J].

Liu, Suling ;

Ginestier, Christophe ;

Charafe-Jauffret, Emmanuelle ;

Foco, Hailey ;

Kleer, Celina G. ;

Merajver, Sofia D. ;

Dontu, Gabriela ;

Wicha, Max S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1680-1685

[47] Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade [J].

Loi, Sherene ;

Haibe-Kains, Benjamin ;

Desmedt, Christine ;

Lallemand, Francoise ;

Tutt, Andrew M. ;

Gillet, Cheryl ;

Ellis, Paul ;

Harris, Adrian ;

Bergh, Jonas ;

Foekens, John A. ;

Klijn, Jan G. M. ;

Larsimont, Denis ;

Buyse, Marc ;

Bontempi, Gianluca ;

Delorenzi, Mauro ;

Piccart, Martine J. ;

Sotiriou, Christos .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (10) :1239-1246

[48] A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer [J].

Ma, Xiao-Jun ;

Salunga, Ranelle ;

Dahiya, Sonika ;

Wang, Wilson ;

Carney, Erin ;

Durbecq, Virginie ;

Harris, Adrian ;

Goss, Paul ;

Sotiriou, Christos ;

Erlander, Mark ;

Sgroi, Dennis .

CLINICAL CANCER RESEARCH, 2008, 14 (09) :2601-2608

[49] The HOXB13:IL7BR expression index is a prognostic factor in early-stage breast cancer [J].

Ma, Xiao-Jun ;

Hilsenbeck, Susan G. ;

Wang, Wilson ;

Ding, Li ;

Sgroi, Dennis C. ;

Bender, Richard A. ;

Osborne, C. Kent ;

Allred, D. Craig ;

Erlander, Mark G. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (28) :4611-4619

[50] A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen [J].

Ma, XJ ;

Wang, ZC ;

Ryan, PD ;

Isakoff, SJ ;

Barmettler, A ;

Fuller, A ;

Muir, B ;

Mohapatra, G ;

Salunga, R ;

Tuggle, JT ;

Tran, Y ;

Tran, D ;

Tassin, A ;

Amon, P ;

Wang, W ;

Enright, E ;

Stecker, K ;

Estepa-Sabal, E ;

Smith, B ;

Younger, J ;

Balis, U ;

Michaelson, J ;

Bhan, A ;

Habin, K ;

Baer, TM ;

Brugge, J ;

Haber, DA ;

Erlander, MG ;

Sgroi, DC .

CANCER CELL, 2004, 5 (06) :607-616

← 1 2 3 4 5 6 7 8 9 10 →