MOLECULAR ORIGINS OF CANCER Gene-Expression Signatures in Breast Cancer

被引：1056

作者：

Sotiriou, Christos ^{[1
]}

Pusztai, Lajos ^{[2
]}

机构：

[1] Univ Libre Bruxelles, Dept Med Oncol, Translat Res Unit, Inst Jules Bordet, B-1000 Brussels, Belgium

[2] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 08期

关键词：

PROGNOSTIC SIGNATURE; HISTOLOGIC GRADE; PREDICT SURVIVAL; CLINICAL UTILITY; MICROARRAY DATA; PROFILES; RECEPTOR; SUBTYPES; RECURRENCE; CARCINOMAS;

D O I：

10.1056/NEJMra0801289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review discusses the results of DNA microarray signatures in breast cancer. These signatures have been useful in the classification of breast cancers, and they have an association with clinical outcomes. Surprisingly, there is little overlap in the types of genes among several useful microarray signatures. The true value of these signatures will become apparent only hen prospective trials, now in progress, have been completed. See P. 790 Copyright © 2009 Massachusetts Medical Society.

引用

页码：790 / 800

页数：11

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