Regulatory networks defining EMT during cancer initiation and progression

被引：2107

作者：

De Craene, Bram

Berx, Geert ^{[1
]}

机构：

[1] Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde, Belgium

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 02期

基金：

欧盟第七框架计划;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR SNAIL; E-CADHERIN REPRESSION; CELL LUNG-CANCER; MAMMARY-GLAND DEVELOPMENT; BREAST-CANCER; GENE-EXPRESSION; DOWN-REGULATION; MIR-200; FAMILY; HISTONE METHYLTRANSFERASE;

D O I：

10.1038/nrc3447

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.

引用

收藏

页码：97 / 110

页数：14

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