IL-18 LEVEL IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING SURGERY OR VALVE REPLACEMENT: WHICH LINK WITH EPICARDIAL FAT DEPOT?

被引：12

作者：

Dozio, E. ^{[1
]}

Dogliotti, G. ^{[1
]}

Malavazos, A. E. ^{[2
]}

Bandera, F. ^{[3
]}

Cassetti, G. ^{[4
]}

Vianello, E. ^{[1
]}

Zelaschi, R. ^{[2
]}

Barassi, A. ^{[5
]}

Pellissero, G. ^{[6
]}

Solimene, U. ^{[1
,7
]}

Morricone, L. ^{[2
]}

Sigruener, A. ^{[8
]}

Tarabin, V. ^{[8
]}

Schmitz, G. ^{[8
]}

Menicanti, L. ^{[4
]}

Romanello, M. M. Corsi ^{[1
,6
]}

机构：

[1] Univ Milan, Dipartimento Sci Biomed Salute, Cattedra Patol Clin, I-20133 Milan, Italy

[2] IRCCS Policlin San Donato, Serv Dietet Nutr Clin & Prevenz Cardiometab, Unita Operat Diabetol & Malattie Metab, Milan, Italy

[3] IRCCS Policlin San Donato, Unita Operat Cardiol, Milan, Italy

[4] IRCCS Policlin San Donato, Unita Operat Cardiochirurg, Milan, Italy

[5] Univ Milan, Dipartimento Sci Salute, Unita Chim & Biochim Analit, I-20133 Milan, Italy

[6] IRCCS Policlin San Donato, Dipartimento Serv Sanit Diag & Cura Med Lab, Unita Operat Lab Patol Clin, Milan, Italy

[7] Univ Milan, Ctr Ric Bioclimatol Med, I-20133 Milan, Italy

[8] Univ Regensburg, Ist Chim Clin & Med Lab, D-93053 Regensburg, Germany

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2012年 / 25卷 / 04期

关键词：

adiposity; cardiovascular diseases; coronary artery bypass grafting surgery; epicardial fat depot; interleukin-18; valve replacement; ADIPOSE-TISSUE; CARDIAC ABNORMALITIES; HEART-DISEASE; INTERLEUKIN-18; EXPRESSION; OBESITY; ADIPOCYTES; CYTOKINES; STENOSIS; CELLS;

D O I：

10.1177/039463201202500418

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Due to the link between obesity, inflammation and cardiovascular diseases, we aimed to measure IL-18 circulating level in patients undergoing open-heart surgery both for elective coronary artery bypass grafting (CABG) or for valve replacement (VR), and we also evaluated whether epicardial adipose tissue (EAT) depot may be a potential source of IL-18. Circulating IL-18 protein was quantified by enzyme-linked immunosorbent assay. IL-18, IL-18 receptor 1 (IL-18 R1) and IL-18 receptor accessory protein (IL-18-RAP) gene expression in EAT depot were evaluated by one colour microarray platform. EAT thickness was measured by echocardiography. In this study we found that all cardiovascular patients (CABG and VR) have increased circulating IL-18 level compared to healthy control subjects (p < 0.0001), but no statistical significant difference was observed between CABG and VR groups (p = 0.35). A great increase in the gene expression of IL-18 (p < 0.05), IL-18 R1 (p < 0.01) and IL-18 RAP (p < 0.001) was observed in EAT samples obtained from CABG vs VR patients. In conclusion, CABG and VR patients had similar increased level of circulating IL-18 protein, but in EAT depots isolated from CABG gene expression of IL-18, IL-18 R1 and IL-18-RAP resulted higher than in VR patients. Future investigation on local IL-18 protein production, its autocrine-paracrine effect and its correlation with plasmatic IL-18 level could give more information on the relationship between IL-18 and coronary artery disease.

引用

页码：1011 / 1020

页数：10

共 31 条

[21] Human epicardial adipose tissue is a source of inflammatory mediators [J].