Alternative cleavage and polyadenylation: extent, regulation and function

被引：678

作者：

Elkon, Ran ^{[1
]}

Ugalde, Alejandro P. ^{[1
]}

Agami, Reuven ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 07期

基金：

欧洲研究理事会;

关键词：

PRE-MESSENGER-RNA; 3' UNTRANSLATED REGIONS; GENOME-WIDE ANALYSIS; LARGE-SCALE ANALYSIS; MOLECULAR-MECHANISMS; FACTOR IM; SIGNAL; POLY(A); TRANSLATION; EXPRESSION;

D O I：

10.1038/nrg3482

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The 3' end of most protein-coding genes and long non-coding RNAs is cleaved and polyadenylated. Recent discoveries have revealed that a large proportion of these genes contains more than one polyadenylation site. Therefore, alternative polyadenylation (APA) is a widespread phenomenon, generating mRNAs with alternative 3' ends. APA contributes to the complexity of the transcriptome by generating isoforms that differ either in their coding sequence or in their 3' untranslated regions (UTRs), thereby potentially regulating the function, stability, localization and translation efficiency of target RNAs. Here, we review our current understanding of the polyadenylation process and the latest progress in the identification of APA events, mechanisms that regulate poly(A) site selection, and biological processes and diseases resulting from APA.

引用

页码：496 / 506

页数：11

共 89 条

[1]

Estrogen-induced upregulation and 3′-UTR shortening of CDC6 [J].

Akman, Begum H. ;

Can, Tolga ;

Erson-Bensan, A. Elif .

NUCLEIC ACIDS RESEARCH, 2012, 40 (21) :10679-10688

[2]

To localize or not to localize: mRNA fate is in 3′UTR ends [J].

Andreassi, Catia ;

Riccio, Antonella .

TRENDS IN CELL BIOLOGY, 2009, 19 (09) :465-474

[3]

BARTH ML, 1993, HUM GENET, V91, P73

[4]

CPEB1 coordinates alternative 3′ -UTR formation with translational regulation [J].

Bava, Felice-Alessio ;

Eliscovich, Carolina ;

Ferreira, Pedro G. ;

Minana, Belen ;

Ben-Dov, Claudia ;

Guigo, Roderic ;

Valcarcel, Juan ;

Mendez, Raul .

NATURE, 2013, 495 (7439) :121-125

[5]

Patterns of variant polyadenylation signal usage in human genes [J].

Beaudoing, E ;

Freier, S ;

Wyatt, JR ;

Claverie, JM ;

Gautheret, D .

GENOME RESEARCH, 2000, 10 (07) :1001-1010

[6]

3′-End Sequencing for Expression Quantification (3SEQ) from Archival Tumor Samples [J].

Beck, Andrew H. ;

Weng, Ziming ;

Witten, Daniela M. ;

Zhu, Shirley ;

Foley, Joseph W. ;

Lacroute, Phil ;

Smith, Cheryl L. ;

Tibshirani, Robert ;

van de Rijn, Matt ;

Sidow, Arend ;

West, Robert B. .

PLOS ONE, 2010, 5 (01)

[7]

A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA) leads to the IPEX syndrome [J].

Bennett, CL ;

Brunkow, ME ;

Ramsdell, F ;

O'Briant, KC ;

Zhu, Q ;

Fuleihan, RL ;

Shigeoka, AO ;

Ochs, HD ;

Chance, PF .

IMMUNOGENETICS, 2001, 53 (06) :435-439

[8]

U1 snRNP Determines mRNA Length and Regulates Isoform Expression [J].

Berg, Michael G. ;

Singh, Larry N. ;

Younis, Ihab ;

Liu, Qiang ;

Pinto, Anna Maria ;

Kaida, Daisuke ;

Zhang, Zhenxi ;

Cho, Sungchan ;

Sherrill-Mix, Scott ;

Wan, Lili ;

Dreyfuss, Gideon .

CELL, 2012, 150 (01) :53-64

[9]

A mechanism for the regulation of pre-mRNA 3′ processing by human cleavage factor Im [J].

Brown, KM ;

Gilmartin, GM .

MOLECULAR CELL, 2003, 12 (06) :1467-1476

[10]

Polypyrimidine tract binding protein modulates efficiency of polyadenylation [J].

Castelo-Branco, P ;

Furger, A ;

Wollerton, M ;

Smith, C ;

Moreira, A ;

Proudfoot, N .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (10) :4174-4183

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