Affinity prediction for substrates of the peptide transporter PepT1

被引：23

作者：

Bailey, PD

Boyd, CAR

Collier, ID

George, JP

Kellett, GL

Meredith, D

Morgan, KM

Pettecrew, R

Price, RA

机构：

[1] Univ Manchester, Sch Chem, Manchester M60 1QD, Lancs, England

[2] Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England

[3] Heriot Watt Univ, Sch EPS Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[4] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 03期

关键词：

D O I：

10.1039/b511996k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.

引用

页码：323 / 325

页数：3

共 28 条

[1]

AMIDON GL, 1994, ANNU REV PHARMACOL, V34, P321

[2] Conformational and spacial preferences for substrates of PepT1 [J].

Bailey, PD ;

Boyd, CAR ;

Collier, ID ;

George, JG ;

Kellett, GL ;

Meredith, D ;

Morgan, KM ;

Pettecrew, R ;

Price, RA ;

Pritchard, RG .

CHEMICAL COMMUNICATIONS, 2005, (42) :5352-5354

[3] Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter [J].

Bailey, PD ;

Boyd, CAR ;

Collier, ID ;

Kellett, GL ;

Meredith, D ;

Morgan, KM ;

Pettecrew, R ;

Price, RA .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, 3 (22) :4038-4039

[4]

Bailey PD, 2000, ANGEW CHEM INT EDIT, V39, P506

[5] Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir [J].

Balimane, PV ;

Tamai, I ;

Guo, AL ;

Nakanishi, T ;

Kitada, H ;

Leibach, FH ;

Tsuji, A ;

Sinko, PJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 250 (02) :246-251

[6] Three-dimensional quantitative structure-activity relationship analyses of β-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1 [J].

Biegel, A ;

Gebauer, S ;

Hartrodt, B ;

Brandsch, M ;

Neubert, K ;

Thondorf, I .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) :4410-4419

[7] Transport of amino acid aryl amides by the intestinal H+/peptide cotransport system, PEPT1 [J].

Börner, V ;

Fei, YJ ;

Hartrodt, B ;

Ganapathy, V ;

Leibach, FH ;

Neubert, K ;

Brandsch, M .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 255 (03) :698-702

[8] Evidence for the absolute conformational specificity of the intestinal H+/peptide symporter, PEPT1 [J].

Brandsch, M ;

Thunecke, F ;

Küllertz, G ;

Schutkowski, M ;

Fischer, G ;

Neubert, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (07) :3861-3864

[9] Molecular and integrative physiology of intestinal peptide transport [J].

Daniel, H .

ANNUAL REVIEW OF PHYSIOLOGY, 2004, 66 :361-384

[10]

DANIEL H, 1992, J BIOL CHEM, V267, P9565

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