Viral and cellular messenger RNA targets of viral microRNAs

被引：223

作者：

Cullen, Bryan R. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Ctr Virol, Durham, NC 27710 USA

来源：

NATURE | 2009年 / 457卷 / 7228期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; IDENTIFICATION; NEUROVIRULENCE; TRANSLATION; INFECTION; ORTHOLOG; ENCODES; PROTEIN;

D O I：

10.1038/nature07757

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Given the propensity of viruses to co- opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA- interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic ( or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.

引用

页码：421 / 425

页数：5

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