Interleukin-1 beta specifically stimulates nitric oxide production in the hypothalamus

被引：11

作者：

Brunetti, L

Volpe, AR

Ragazzoni, E

Preziosi, P

Vacca, M

机构：

[1] UNIV G DANNUNZIO, FAC FARM, INST SCI FARM, I-66100 CHIETI, ITALY

[2] CATHOLIC UNIV, CNR, RECEPTOR CHEM CTR, I-00168 ROME, ITALY

来源：

LIFE SCIENCES | 1996年 / 58卷 / 25期

关键词：

interleukin-1; beta; nitric oxide; CRH;

D O I：

10.1016/0024-3205(96)00238-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In previous experiments we have shown the role of nitric oxide (NO) in basal and interleukin-1 beta (IL-1 beta)-induced CRH and ACTH release in vitro. Now, we have studied the possible production of NO from hypothalamic cell cultures, particularly after IL-1 beta stimulation or L-NOArg inhibition, by high performance liquid chromatographic (HPLC) assay of L-citrulline production, adding further evidence for a role of NO in IL-1 beta activity in the hypothalamus.

引用

收藏

页码：PL373 / PL377

页数：5

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