Tec Family Kinases in Inflammation and Disease

被引：65

作者：

Horwood, Nicole J. ^{[1
]}

Urbaniak, Ania M. ^{[1
]}

Danks, Lynett ^{[1
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, London W6 8LH, England

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2012年 / 31卷 / 02期

关键词：

tyrosine kinase; arthritis; btk; inflammation; BRUTONS-TYROSINE-KINASE; NF-KAPPA-B; X-LINKED AGAMMAGLOBULINEMIA; CELL ANTIGEN RECEPTOR; TUMOR-NECROSIS-FACTOR; FC-GAMMA-RIIB; COLLAGEN-INDUCED ARTHRITIS; INNATE IMMUNE-RESPONSES; TNF-ALPHA PRODUCTION; RHEUMATOID-ARTHRITIS;

D O I：

10.3109/08830185.2012.670334

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.

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页码：87 / 103

页数：17

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