Cell Culture Models in Microfluidic Systems

被引：257

作者：

Meyvantsson, Ivar ^{[1
]}

Beebe, David J. ^{[2
]}

机构：

[1] Bellbrook Labs LLC, Madison, WI 53711 USA

[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY | 2008年 / 1卷

关键词：

microenvironment; extracellular matrix; microfabrication;

D O I：

10.1146/annurev.anchem.1.031207.113042

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Microfluidic technology holds great promise for the creation of advanced cell culture models. In this review, we discuss the characterization of cell cult-Lire in microfluidic systems, describe important biochemical and physical features of the cell microenvironment, and review studies of microfluidic cell manipulation in the context of these features. Finally, we consider the integration of analytical elements, ways to achieve high throughput, and the design constraints imposed by cell biology applications.

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收藏

页码：423 / 449

页数：27

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