Manipulation and tracking of superparamagnetic nanoparticles using MRI

被引：16

作者：

Darton, Nicholas J. ^{[1
]}

Sederman, Andrew J. ^{[1
]}

Ionescu, Adrian ^{[2
]}

Ducati, Caterina ^{[3
]}

Darton, RichardC ^{[4
]}

Gladden, Lynn F. ^{[1
]}

Slater, Nigel K. H. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem Engn, New Museums Site, Cambridge CB2 3RA, England

[2] Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England

[3] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3QZ, England

[4] Univ Oxford, Dept Engn Sci, Oxford OX1 2JD, England

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 39期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1088/0957-4484/19/39/395102

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The use of magnetic fields in magnetic resonance imaging (MRI) for the tracking and delivery of chemotherapeutics bound to superparamagnetic nanoparticles offers a promising method for the non-invasive treatment of inoperable tumours. Here we demonstrate that superparamagnetic magnetite nanoparticles fabricated by an easily scalable method can be driven and tracked in real time at high velocities in vitro using MRI hardware. Force balance calculations are consistent with the magnetic properties of individual 10 nm diameter particles that move collectively as micron sized agglomerates with hydrodynamic diameter similar to that inferred from zero-magnetic-field dynamic light scattering measurements.

引用

页数：5

共 12 条

[11] Hepatocellular carcinoma: Regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite - Initial experience with four patients
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