Role of MicroRNAs in Lung Disease

被引：95

作者：

Angulo, Martin ^{[1
,2
]}

Lecuona, Emilia ^{[1
]}

Iasha Sznajder, Jacob ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care, Chicago, IL 60611 USA

[2] Univ Republica, Fac Med, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay

来源：

ARCHIVOS DE BRONCONEUMOLOGIA | 2012年 / 48卷 / 09期

关键词：

MicroRNA; Lung disease; Smoking; Chronic obstructive pulmonary disease; Lung cancer; Pulmonary fibrosis; Lung injury; Asthma; OBSTRUCTIVE PULMONARY-DISEASE; DOWN-REGULATION; REDUCED EXPRESSION; CANCER; SURVIVAL; TARGET; MUSCLE; SPUTUM; CELLS; IDENTIFICATION;

D O I：

10.1016/j.arbres.2012.04.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications. (C) 2012 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.

引用

页码：325 / 330

页数：6

共 76 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
Bartel, David P.
[J]. CELL, 2007, 131 (04) : 11 - 29
[2] Cai ZG, 2012, CAN J PHYSIOL PHARM, V90, P37, DOI [10.1139/Y11-095, 10.1139/y11-095]
[3] Secreted microRNAs: a new form of intercellular communication
Chen, Xi
Liang, Hongwei
Zhang, Junfeng
Zen, Ke
Zhang, Chen-Yu
[J]. TRENDS IN CELL BIOLOGY, 2012, 22 (03) : 125 - 132
[4] MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma
Chiba, Yoshihiko
Misawa, Miwa
[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 114 (03) : 264 - 268
[5] MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
Crawford, Melissa
Batte, Kara
Yu, Lianbo
Wu, Xin
Nuovo, Gerard J.
Marsh, Clay B.
Otterson, Gregory A.
Nana-Sinkam, Serge P.
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 388 (03) : 483 - 489
[6] miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis
Cushing, Leah
Kuang, Ping Ping
Qian, Jun
Shao, Fengzhi
Wu, Junjie
Little, Frederic
Thannickal, Victor J.
Cardoso, Wellington V.
Lue, Jining
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 45 (02) : 287 - 294
[7] MicroRNA-218 Is Deleted and Downregulated in Lung Squamous Cell Carcinoma
Davidson, Morgan R.
Larsen, Jill E.
Yang, Ian A.
Hayward, Nicholas K.
Clarke, Belinda E.
Duhig, Edwina E.
Passmore, Linda H.
Bowman, Rayleen V.
Fong, Kwun M.
[J]. PLOS ONE, 2010, 5 (09): : 1 - 10
[8] Mechanisms of control of microRNA biogenesis
Davis-Dusenbery, Brandi N.
Hata, Akiko
[J]. JOURNAL OF BIOCHEMISTRY, 2010, 148 (04) : 381 - 392
[9] Argonaute proteins at a glance
Ender, Christine
Meister, Gunter
[J]. JOURNAL OF CELL SCIENCE, 2010, 123 (11) : 1819 - 1823
[10] Gene expression networks in COPD: microRNA and mRNA regulation
Ezzie, Michael E.
Crawford, Melissa
Cho, Ji-Hoon
Orellana, Robert
Zhang, Shile
Gelinas, Richard
Batte, Kara
Yu, Lianbo
Nuovo, Gerard
Galas, David
Diaz, Philip
Wang, Kai
Nana-Sinkam, S. Patrick
[J]. THORAX, 2012, 67 (02) : 122 - 131

← 1 2 3 4 5 6 7 8 →