Dicer inactivation causes heterochronic retinogenesis in Xenopus laevis

被引：28

作者：

Decembrini, Sarah ^{[1
]}

Andreazzoli, Massimiliano ^{[1
]}

Barsacchi, Giuseppina ^{[1
]}

Cremisi, Federico ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Biol, I-1356010 Pisa, Italy

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 08期

关键词：

Dicer; miRNA; timing; neuronenesis; retina;

D O I：

10.1387/ijdb.082646sd

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Maturation of miRNAs by dicer is required in vertebrates for normal neural development. Here we report that dicer inactivation in Xenopus affects cell cycle progression, survival and timing of the generation of retinal cells, resulting in small retinas with lamination defects. In particular, dicer inactivation delays the exit from the cell cycle and the translation of key genes of late neurogenesis, highlighting a crucial role of miRNAs in retinal development.

引用

页码：1099 / 1103

页数：5

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