A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes

被引：17

作者：

Araujo, J. R. ^{[1
]}

Ramalho, C. ^{[2
]}

Correia-Branco, A. ^{[1
]}

Faria, A. ^{[1
,3
]}

Ferraz, T. ^{[2
]}

Keating, E. ^{[1
]}

Martel, F. ^{[1
]}

机构：

[1] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200319 Oporto, Portugal

[2] Ctr Hosp S Joao, Dept Obstet & Gynaecol, P-4200319 Oporto, Portugal

[3] Univ Porto, Fac Sci, Dept Chem, Chem Invest Ctr CIQ, P-4169007 Oporto, Portugal

来源：

PLACENTA | 2013年 / 34卷 / 11期

关键词：

Maternal diabetes; Oxidative stress; Placenta; PREGNANCY; MARKERS; MELLITUS; TISSUE; PLASMA; WOMEN;

D O I：

10.1016/j.placenta.2013.09.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1095 / 1098

页数：4

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