One-Year Comparison of a High-Monounsaturated Fat Diet With a High-Carbohydrate Diet in Type 2 Diabetes

被引：149

作者：

Brehm, Bonnie J. ^{[1
]}

Lattin, Barbara L. ^{[1
]}

Summer, Suzanne S. ^{[1
]}

Boback, Jane A. ^{[1
]}

Gilchrist, Gina M. ^{[1
]}

Jandacek, Ronald J. ^{[2
]}

D'Alessio, David A. ^{[2
]}

机构：

[1] Univ Cincinnati, Coll Nursing, Cincinnati, OH USA

[2] Univ Cincinnati, Coll Med, Cincinnati, OH USA

来源：

DIABETES CARE | 2009年 / 32卷 / 02期

基金：

美国国家卫生研究院;

关键词：

WEIGHT-LOSS; FOLLOW-UP; ACIDS; PREVENTION; INTERVENTION; MANAGEMENT; GLUCOSE;

D O I：

10.2337/dc08-0687

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - The purpose of this study was to compare the effects of high-monounsaurated fatty acid (MUFA) and high-carbohydrate (CHO) diets on body weight and glycemic control in men and women with type 2 diabetes. RESEARCH DESIGN AND METHODS - Overweight/obese participants with type 2 diabetes (n = 124, age = 56.5 +/- 0.8 years, BMI = 35.9 +/- 0.3 kg/m(2), and A1C = 7.3 +/- 0.1%) were randomly assigned to 1 year of a high-MUFA or high-CHO diet. Anthropometric and metabolic parameters were assessed at baseline and after 4, 8, and 1.2 months of dieting. RESULTS - Baseline characteristics were similar between the treatment. groups. The overall retention rate for 1. year was 77% (69% for the high-MUFA group and 84% for the high-CHO group; P = 0.06). Based on food records, both groups had similar energy intake but a significant difference in MUFA intake. Both groups had similar weight loss over 1 year (-4.0 +/- 0.8 vs. -3.8 +/- 0.6 kg) and comparable improvement in body fat, waist circumference, diastolic blood pressure, HDL cholesterol, A1C, and fasting glucose and insulin. There were no differences in these parameters between the groups. A follow-up assessment of a subset of participants (n = 36) was conducted 18 months after completion of the 52-week diet. These participants maintained their weight loss and A1C during the follow-up period. CONCLUSIONS - In individuals with type 2 diabetes, high-MUFA diets are an alternative to conventional lower-fat, high-CHO diets with comparable beneficial effects on body Weight, body composition, cardiovascular risk factors, and glycemic control.

引用

页码：215 / 220

页数：6

共 21 条

[11] Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function [J].