New cytotoxic spongian diterpenes from the sponge Dysidea cf. arenaria

被引：24

作者：

Agena, Mika ^{[1
]}

Tanaka, Chiaki ^{[1
]}

Hanif, Novriyandi ^{[2
]}

Yasumoto-Hirose, Mina ^{[1
]}

Tanaka, Junichi ^{[1
]}

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan

[2] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

TETRAHEDRON | 2009年 / 65卷 / 07期

关键词：

Marine natural products; Sponge; Diterpene; cytotoxicity; METABOLITES; HERBACEA;

D O I：

10.1016/j.tet.2008.11.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Seven new (1-7) and three known (8-10) spongian-class diterpenes have been isolated from the sponge Dysidea cf. arenaria collected in Okinawa. Compound 6 was also isolated from the nudibranch Chromodoris kuniei. The structures of the new entities were elucidated by spectroscopic analyses. Three of the new spongians (2, 6, and 7) showed cytotoxicity against NBT-T2 rat bladder epithelial cells. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1495 / 1499

页数：5

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