The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?

被引：167

作者：

Wadenberg, MLG ^{[1
]}

Hicks, PB ^{[1
]}

机构：

[1] Scott & White Mem Hosp & Clin, Dept Psychiat, Temple, TX 75608 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1999年 / 23卷 / 06期

基金：

瑞典研究理事会;

关键词：

conditioned avoidance response; antipsychotic drugs; brain neurotransmitter receptors; nucleus accumbens(shell); rat;

D O I：

10.1016/S0149-7634(99)00037-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present review discusses the history and paradigm of the conditioned avoidance response (CAR) in rats for the detection of potential antipsychotic activity of drugs. In addition, the role of dopamine (DA) D-2, serotonin (5-HT)(2A/2C) alpha(1), 5-HT, DA D-4 muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated. Finally, data investigating brain sites of action for the mediation of CAR behavior is discussed. It is concluded that the CAR test, originally found to be sensitive for the detection of antipsychotic drugs with high affinity as antagonists for brain dopamine receptors, is also sensitive for the detection of potentially antipsychotic compounds acting primarily via neurotransmitter receptors other than the DA D-2 receptor. Furthermore, the review confirms the importance of the nucleus accumbens(shell) in the mediation of effects on CAR produced by traditional, as well as atypical antipsychotic drugs. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：851 / 862

页数：12

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