Fueling the flame: bioenergy couples metabolism and inflammation

被引：113

作者：

Liu, Tie Fu ^{[1
]}

Brown, Candice M. ^{[1
,5
]}

El Gazzar, Mohamed ^{[6
]}

McPhail, Linda ^{[2
]}

Millet, Patrick ^{[1
]}

Rao, Anuradha ^{[1
]}

Vachharajani, Vidula T. ^{[3
]}

Yoza, Barbara K. ^{[1
,4
]}

McCall, Charles E. ^{[1
,6
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Mol Med, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Dept Anesthesiol, Winston Salem, NC 27157 USA

[4] Wake Forest Univ, Bowman Gray Sch Med, Div Surg Sci, Winston Salem, NC 27157 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Translat Sci Inst, Winston Salem, NC 27157 USA

[6] E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2012年 / 92卷 / 03期

基金：

美国国家卫生研究院;

关键词：

AMP; epigenetics; fatty acid oxidation; glycolysis; HIF-1; alpha; NAD(+); Nampt; obesity; PGC-1; sepsis; NF-KAPPA-B; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; TRANSCRIPTIONAL REGULATION; MITOCHONDRIAL BIOGENESIS; EPIGENETIC REGULATION; OXIDATIVE-METABOLISM; GLUCOSE-HOMEOSTASIS; GENE-EXPRESSION; SIRT6; PGC-1-ALPHA;

D O I：

10.1189/jlb.0212078

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We review the emerging concept that changes in cellular bioenergetics concomitantly reprogram inflammatory and metabolic responses. The molecular pathways of this integrative process modify innate and adaptive immune reactions associated with inflammation, as well as influencing the physiology of adjacent tissue and organs. The initiating proinflammatory phase of inflammation is anabolic and requires glucose as the primary fuel, whereas the opposing adaptation phase is catabolic and requires fatty acid oxidation. The fuel switch to fatty acid oxidation depends on the sensing of AMP and NAD(+) by AMPK and the SirT family of deacetylases (e.g., SirT1, -6, and -3), respectively, which couple inflammation and metabolism by chromatin and protein reprogramming. The AMP-AMPK/NAD(+)-SirT axis proceeds sequentially during acute systemic inflammation associated with sepsis but ceases during chronic inflammation associated with diabetes, obesity, and atherosclerosis. Rebalancing bioenergetics resolves inflammation. Manipulating cellular bioenergetics is identifying new ways to treat inflammatory and immune diseases. J. Leukoc. Biol. 92: 499-507; 2012.

引用

页码：499 / 507

页数：9

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