Pituitary autoimmunity: 30 years later

被引：133

作者：

Caturegli, Patrizio ^{[1
,2
]}

Lupi, Isabella ^{[3
]}

Landek-Salgado, Melissa ^{[1
]}

Kimura, Hiroaki ^{[1
]}

Rose, Noel R. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA

[3] Univ Pisa, Dept Endocrinol & Metab, Pisa, Italy

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 7卷 / 08期

关键词：

Hypophysitis; Pituitary antigens; Pituitary antibodies;

D O I：

10.1016/j.autrev.2008.04.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：631 / 637

页数：7

共 40 条

[31] LYMPHOID HYPOPHYSITIS WITH SELECTIVE ADRENOCORTICOTROPIC HORMONE DEFICIENCY [J].