Multifunctional Analytical Platform on a Paper Strip: Separation, Preconcentration, and Subattomolar Detection

被引：141

作者：

Abbas, Abdennour ^{[1
]}

Brimer, Andrew ^{[1
]}

Slocik, Joseph M. ^{[2
]}

Tian, Limei ^{[1
]}

Naik, Rajesh R. ^{[2
]}

Singamaneni, Srikanth ^{[1
]}

机构：

[1] Washington Univ, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA

[2] Mat & Mfg Directorate, Soft Matter Mat Branch, Dayton, OH 45433 USA

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 08期

关键词：

ENHANCED RAMAN-SPECTROSCOPY; ANALYTICAL DEVICE; GOLD NANORODS; NANOSTRUCTURES; SENSOR; ARRAY;

D O I：

10.1021/ac303567g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10(-18) M) detection limit using surface-enhanced Raman scattering as a transduction method. The microfluidic paper-based analytical device (mu PAD) is made with a lithography-free process by a simple cut and drop method. Complex samples are separated by a surface chemical gradient created by differential polyelectrolyte coating of the paper. The mu PAD with a starlike shape is designed to enable liquid handling by lateral flow without microchannel patterning. This design generates a rapid capillary-driven flow capable of dragging liquid samples as well as gold nanorods into a single cellulose microfiber, thereby providing an extremely preconcentrated and optically active detection spot.

引用

页码：3977 / 3983

页数：7

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