Diastereoselective synthesis of protected syn 1,3-diols:: Preparation of the C16-C24 portion of dolabelides

被引：30

作者：

Grimaud, L

de Mesmay, R

Prunet, J ^{[1
]}

机构：

[1] Ecole Polytech, DCSO, CNRS, UMR 7652,Lab Synth Organ, F-91128 Palaiseau, France

[2] Ecole Natl Super Tech Avancees, Lab Chim & Proc, F-75015 Paris, France

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 03期

关键词：

D O I：

10.1021/ol017122w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have designed a new method to make synthons encompassing a protected syn 1,3-diol motif and an aldehyde a to the 1,3-dioxane ring. An additional stereocenter was also created, potentially leading to stereochemically defined 1,2,4-triols. This method was successfully applied to the synthesis of the C16-C24 portion of Dolabelides.

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页码：419 / 421

页数：3

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