Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging Contrast Agent

被引：77

作者：

Zhao, Xueling ^{[1
,2
]}

Zhao, Hongli ^{[3
]}

Chen, Zongyan ^{[1
,2
]}

Lan, Minbo ^{[3
,4
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China

[4] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2014年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Ultrasmall Superparamagnetic Iron Oxides (USPIOs); Magnetic Resonance Imaging (MRI); Contrast Agent; Reticuloendothelial System (RES); Blood Brain Barrier (BBB); LYMPH-NODE METASTASES; BLOOD-POOL AGENT; MR-ANGIOGRAPHY; ATHEROSCLEROTIC PLAQUES; NC100150; INJECTION; DRUG-DELIVERY; PARTICLES; NANOCRYSTALS; FE; CO;

D O I：

10.1166/jnn.2014.9192

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of various types of diseases. In particular, ultrasmall superparamagnetic iron oxides (USPIOs) have been investigated in many biological applications, both in vitro and in vivo. Due to their small size (diameter <20 nm), these particles are not immediately removed from the circulation by the reticuloendothelial system (RES), have a longer blood half-life, a wider biodistribution and allow potential targeting with appropriate bioconjugates to specific tissues both normal and tumorous. This review will mainly discuss the synthesis of USPIOs and their applications as MRI contrast agent for disease detection.

引用

页码：210 / 220

页数：11

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