Growth factor action on ovarian function in polycystic ovary syndrome

被引：22

作者：

Giudice, LC ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Gynecol & Obstet, Div REprod Endocrinol & Infertil, Stanford, CA 94305 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0889-8529(05)70072-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like growth factors, their receptors, binding proteins, and binding protein proteases are important in normal and abnormal ovarian follicle development. IGFs stimulate ovarian cellular mitosis and steroidogenesis and inhibit apoptosis. Patterns of expression of IGF family members are characterisitic of whether follicles are estrogen- or androgen-dominant. The PCOS follicle is androgen-dominant but does not appear to be atretic and has characteristic IGF family expression. Available data strongly support an intraovarian, as opposed to endocrine, role for this growth factor family in ovarian follicle growth, steroidogenesis, and atresia.

引用

页码：325 / +

页数：16

共 117 条

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