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Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

被引：5
作者：
Carpenter, KJ
Buckland, KF
Xing, Z
Hogaboam, CM
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期
关键词：
D O I：
10.1128/IAI.73.12.8402-8406.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.
引用
收藏
页码：8402 / 8406
页数：5
相关论文
共 38 条
  • [1] The role of the DAP12 signal in mouse myeloid differentiation
    Aoki, N
    Kimura, S
    Takiyama, Y
    Atsuta, Y
    Abe, A
    Sato, K
    Katagiri, M
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (07) : 3790 - 3796
  • [2] Role of DAP12 in innate and adaptive immune responses
    Aoki, N
    Kimura, S
    Xing, Z
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (01) : 7 - 10
  • [3] Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection
    Aoki, N
    Zganiacz, A
    Margetts, P
    Xing, Z
    [J]. INFECTION AND IMMUNITY, 2004, 72 (05) : 2477 - 2483
  • [4] DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    Bakker, ABH
    Hoek, RM
    Cerwenka, A
    Blom, B
    Lucian, L
    McNeil, T
    Murray, R
    Phillips, JH
    Sedgwick, JD
    Lanier, LL
    [J]. IMMUNITY, 2000, 13 (03) : 345 - 353
  • [5] A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Bleharski, JR
    Kiessler, V
    Buonsanti, C
    Sieling, PA
    Stenger, S
    Colonna, M
    Modlin, RL
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (07) : 3812 - 3818
  • [6] A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    Bouchon, A
    Hernández-Munain, C
    Cella, M
    Colonna, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (08) : 1111 - 1122
  • [7] Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    Bouchon, A
    Dietrich, J
    Colonna, M
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (10) : 4991 - 4995
  • [8] TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    Bouchon, A
    Facchetti, F
    Weigand, MA
    Colonna, M
    [J]. NATURE, 2001, 410 (6832) : 1103 - 1107
  • [9] A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
    Bozza, S
    Perruccio, K
    Montagnoli, C
    Gaziano, R
    Bellocchio, S
    Burchielli, E
    Nkwanyuo, G
    Pitzurra, L
    Velardi, A
    Romani, L
    [J]. BLOOD, 2003, 102 (10) : 3807 - 3814
  • [10] Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants
    Bozza, S
    Gaziano, R
    Lipford, GB
    Montagnoli, C
    Bacci, A
    Di Francesco, P
    Kurup, VP
    Wagner, H
    Romani, L
    [J]. MICROBES AND INFECTION, 2002, 4 (13) : 1281 - 1290
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