Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings

被引:510
作者
Cucinotta, Francis A. [1 ]
Durante, Marco
机构
[1] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA
[2] Univ Naples Federico II, Dept Phys, Naples, Italy
[3] Univ Naples Federico II, Natl Inst Nucl Phys, Naples, Italy
关键词
D O I
10.1016/S1470-2045(06)70695-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Space programmes are shifting toward planetary exploration, and in particular towards missions by human beings to the moon and Mars. However, exposure to space radiation is an important barrier to exploration of the solar system by human beings because of the biological effects of high-energy heavy ions. These ions have a high charge and energy, are the main contributors to radiation risk in deep space, and their biological effects are understood poorly. Predictions of the nature and magnitude of risks posed by exposure to radiation in space are subject to many uncertainties. In recent years, worldwide efforts have focussed on an increased understanding of the oncogenic potential of galactic cosmic rays. A review of the new results in this specialty will be presented here.
引用
收藏
页码:431 / 435
页数:5
相关论文
共 53 条
[1]   TUMORIGENIC POTENTIAL OF HIGH-Z, HIGH-LET CHARGED-PARTICLE RADIATIONS [J].
ALPEN, EL ;
POWERSRISIUS, P ;
CURTIS, SB ;
DEGUZMAN, R .
RADIATION RESEARCH, 1993, 136 (03) :382-391
[2]   Radiotherapy with beams of carbon ions [J].
Amaldi, U ;
Kraft, G .
REPORTS ON PROGRESS IN PHYSICS, 2005, 68 (08) :1861-1882
[3]   M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements [J].
Anderson, RM ;
Stevens, DL ;
Goodhead, DT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12167-12172
[4]   Radiation and the microenvironment - Tumorigenesis and therapy [J].
Barcellos-Hoff, MH ;
Park, C ;
Wright, EG .
NATURE REVIEWS CANCER, 2005, 5 (11) :867-875
[5]   Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away [J].
Belyakov, OV ;
Mitchell, SA ;
Parikh, D ;
Randers-Pehrson, G ;
Marino, SA ;
Amundson, SA ;
Geard, CR ;
Brenner, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (40) :14203-14208
[6]   Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness [J].
Blakely, EA ;
Kronenberg, A .
RADIATION RESEARCH, 1998, 150 (05) :S126-S145
[7]   Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know [J].
Brenner, DJ ;
Doll, R ;
Goodhead, DT ;
Hall, EJ ;
Land, CE ;
Little, JB ;
Lubin, JH ;
Preston, DL ;
Preston, RJ ;
Puskin, JS ;
Ron, E ;
Sachs, RK ;
Samet, JM ;
Setlow, RB ;
Zaider, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :13761-13766
[8]   THE LOW CARCINOGENICITY OF ELECTRON-RADIATION RELATIVE TO ARGON IONS IN RAT SKIN [J].
BURNS, FJ ;
JIN, Y ;
KOENIG, KL ;
HOSSELET, S .
RADIATION RESEARCH, 1993, 135 (02) :178-188
[9]   Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].
Celeste, A ;
Fernandez-Capetillo, O ;
Kruhlak, MJ ;
Pilch, DR ;
Staudt, DW ;
Lee, A ;
Bonner, RF ;
Bonner, WM ;
Nussenzweig, A .
NATURE CELL BIOLOGY, 2003, 5 (07) :675-U51
[10]   Effects of iron ions, protons and X rays on human lens cell differentiation [J].
Chang, PY ;
Bjornstad, KA ;
Rosen, CJ ;
McNamara, MP ;
Mancini, R ;
Goldstein, LE ;
Chylack, LT ;
Blakely, EA .
RADIATION RESEARCH, 2005, 164 (04) :531-539