A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192 .2. Biological activities

被引：20

作者：

Kawase, Y

Takahashi, M

Takatsu, T

Arai, M

Nakajima, M

Tanzawa, K

机构：

[1] SANKYO CO LTD,BIOMED RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期

关键词：

D O I：

10.7164/antibiotics.49.61

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Inhibitory activities of A-72363 A-1, A-2, and C, the diastereomers of a neuraminidase inhibitor siastain B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound showed strikingly different specificities towards the various glycosidases tested. A-72363 C inhibited bovine liver beta-glucuronidase and tumor cell heparanase with IC50 values of 1.6 mu M and 12 mu M, respectively.

引用

页码：61 / 64

页数：4

共 14 条

[1] NAGSTATIN, A NEW INHIBITOR OF N-ACETYL-BETA-D-GLUCOSAMINIDASE, PRODUCED BY STREPTOMYCES-AMAKUSAENSIS MG846-FF3 - TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
AOYAGI, T
SUDA, H
UOTANI, K
KOJIMA, F
AOYAMA, T
HORIGUCHI, K
HAMADA, M
TAKEUCHI, T
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (09) : 1404 - 1408
[2] CXC CHEMOKINES CONNECTIVE-TISSUE ACTIVATING PEPTIDE-III AND NEUTROPHIL-ACTIVATING PEPTIDE-2 ARE HEPARIN HEPARAN SULFATE-DEGRADING ENZYMES
HOOGEWERF, AJ
LEONE, JW
REARDON, IM
HOWE, WJ
ASA, D
HEINRIKSON, RL
LEDBETTER, SR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) : 3268 - 3277
[3] CHEMICALLY MODIFIED HEPARINS AS INHIBITORS OF HEPARAN-SULFATE SPECIFIC ENDO-BETA-GLUCURONIDASE (HEPARANASE) OF METASTATIC MELANOMA-CELLS
IRIMURA, T
NAKAJIMA, M
NICOLSON, GL
[J]. BIOCHEMISTRY, 1986, 25 (18) : 5322 - 5328
[4] SYNTHESES OF THE POTENT INHIBITORS OF NEURAMINIDASE, N-(1,2-DIHYDROXYPROPYL) DERIVATIVES OF SIASTATIN-B AND ITS 4-DEOXY ANALOGS
KUDO, T
NISHIMURA, Y
KONDO, S
TAKEUCHI, T
[J]. JOURNAL OF ANTIBIOTICS, 1993, 46 (02) : 300 - 309
[5] HEPARAN-SULFATE DEGRADATION - RELATION TO TUMOR INVASIVE AND METASTATIC PROPERTIES OF MOUSE B-16 MELANOMA SUBLINES
NAKAJIMA, M
IRIMURA, T
DIFERRANTE, D
DIFERRANTE, N
NICOLSON, GL
[J]. SCIENCE, 1983, 220 (4597) : 611 - 613
[6] NAKAJIMA M, 1991, J BIOL CHEM, V266, P9661
[7] A SOLID-PHASE SUBSTRATE OF HEPARANASE - ITS APPLICATION TO ASSAY OF HUMAN-MELANOMA FOR HEPARAN-SULFATE DEGRADATIVE ACTIVITY
NAKAJIMA, M
IRIMURA, T
NICOLSON, GL
[J]. ANALYTICAL BIOCHEMISTRY, 1986, 157 (01) : 162 - 171
[8] TOTALLY SYNTHETIC ANALOGS OF SIASTATIN-B .3. TRIFLUOROACETAMIDE ANALOGS HAVING INHIBITORY ACTIVITY FOR TUMOR-METASTASIS
NISHIMURA, Y
KUDO, T
KONDO, S
TAKEUCHI, T
TSURUOKA, T
FUKUYASU, H
SHIBAHARA, S
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (01) : 101 - 107
[9] SYNTHESIS OF 3-EPISIASTATIN-B ANALOGS HAVING ANTIINFLUENZA VIRUS ACTIVITY
NISHIMURA, Y
UMEZAWA, Y
KONDO, S
TAKEUCHI, T
MORI, K
KIJIMASUDA, I
TOMITA, K
SUGAWARA, K
NAKAMURA, K
[J]. JOURNAL OF ANTIBIOTICS, 1993, 46 (12) : 1883 - 1889
[10] SAIKI I, 1990, CANCER RES, V50, P3631

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