Continuous-Flow Synthesis of 1-Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence

被引：77

作者：

Chen, Mao ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 15期

关键词：

cross-coupling; flow chemistry; microreactors; palladium; synthetic methods; ORGANIC-SYNTHESIS; HYDROGENATION REACTIONS; MULTISTEP SYNTHESIS; DERIVATIVES; REACTORS; MICROREACTOR; CHEMISTRY; ARYLATION; AMINATION; TRIAZOLE;

D O I：

10.1002/anie.201300615

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two approaches have been developed for the regiospecific continuous-flow synthesis of 1-substituted benzotriazoles. They begin with either an S NAr reaction at high temperature or Pd catalysis and involve consecutive multiphase processes, allowing the multistep synthesis of benzotriazoles to take place in an efficient manner (see picture). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4247 / 4250

页数：4

共 66 条

[1]

[Anonymous], 2012, ANGEW CHEM

[2]

Baxendale I. R., 2009, ANGEW CHEM, V121, P4077

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