Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts

被引：85

作者：

Chernyak, Natalia ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 30期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CATALYZED ALPHA-ARYLATION; ARYL METHYL KETONES; CROSS-COUPLINGS; MEERWEIN ARYLATION; DIAZONIUM SALTS; PALLADIUM; ALDEHYDES; ESTERS; CHEMISTRY; FERROCENE;

D O I：

10.1021/ja305660a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the alpha-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

引用

收藏

页码：12466 / 12469

页数：4

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