TiCl4-Catalyzed indirect anti-markovnikov hydration of alkynes:: Application to the synthesis of benzo[b]furans

被引：134

作者：

Ackermann, Lutz

Kaspar, Ludwig T.

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 16期

关键词：

D O I：

10.1021/jo070887i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzo[b]furans.

引用

页码：6149 / 6153

页数：5

共 61 条

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